Anti-TSHR抗體,促甲狀腺素受體抗體說(shuō)明 返回列表頁(yè)

     Anti-TSHR抗體,促甲狀腺素受體抗體說(shuō)明產(chǎn)品介紹：The glycoprotein hormone receptor family consists of the luteinizing hormone receptor, the follicle-stimulating hormone receptor, and the thyroid stimulating hormone(TSH) receptor. TSH, which is released from the pituitary gland, binds to the TSH receptor on thyroid cells to control size and function of the thyroid gland (De Felice et al. 2004). The TSH receptor signals through Gs to elevate intracellular cAMP in the thyroid gland, which regulates iodide uptake, and transcription of thyroglobulin (Tg), thyroid peroxidase (TPO), and sodium-iodide symporter. The TSH receptor also signals Gq and phospholipase C to regulat iodide efflux, H2O2 production, and thyroglobulin iodination. Autoimmunity to the TSH receptor causes hyperthyroidism (Graves disease) or hypothyroidism (Hashimoto thyroiditis) when the autoantibodies function as agonists or antagonists, respectively, at the TSH receptor (Rapoport and McLachlan, 2001; Davies et al., 2002). Millipore’s cloned human TSH receptor-expressing cell line is made in the Chem-10 host, which supports high levels of recombinant TSH receptor expression on the cell surface and contains high levels of the promiscuous G protein to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between TSH and its ligands. 

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保存條件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
連續(xù)使用時(shí)4°C存儲(chǔ)，保質(zhì)期六個(gè)月，*存儲(chǔ)時(shí)建議分裝為10ul以上小包裝-20°C存儲(chǔ)，并避免反復(fù)凍融，保質(zhì)期一年。

產(chǎn)品名稱(chēng) Anti-TSHR抗體,促甲狀腺素受體抗體說(shuō)明

產(chǎn)品編號(hào) BYK-0460R

英文名稱(chēng) TSHR
中文名稱(chēng) 促甲狀腺素受體抗體
別    名 hTSHR I; hTSHRI; LGR 3; LGR3; MGC75129; Thyroid adenoma hyperfunctioning; Thyroid carcinoma with thyrotoxicosis; Thyroid Stimulating Hormone Receptor; Thyrotropin Receptor; Thyrotropin receptor I; TSH R; TSHR; Thyroid stimulating hormone receptor; TSHR_HUMAN.
研究領(lǐng)域 生長(zhǎng)因子和激素  細(xì)胞膜受體  內(nèi)分泌病          

抗體來(lái)源 Rabbit or Mouse
克隆類(lèi)型 Polyclonal or Monoclonal
交叉反應(yīng)、產(chǎn)品應(yīng)用 （具體交叉反應(yīng)與產(chǎn)品應(yīng)用請(qǐng)）

    Anti-TSHR抗體,促甲狀腺素受體抗體說(shuō)明更多優(yōu)質(zhì)產(chǎn)品有：

*抗體 Anti-GRIH
核纖層蛋白B2抗體 Anti-Lamin B2
溶質(zhì)攜帶物家族1抗體 Anti-SLC1A5
超氧化物歧化酶2抗體 Anti-SOD2 
髓鞘蛋白P0樣蛋白2抗體 Anti-MPZL2/EVA1 
超氧化物歧化酶1抗體(銅/鋅過(guò)氧化物歧化酶SOD) Anti-SOD1/SOD
鈣粘附蛋白9抗體 Anti-Cadherin 9
細(xì)胞因子信號(hào)傳導(dǎo)抑制蛋白3抗體 Anti-SOCS3
細(xì)胞因子信號(hào)傳導(dǎo)抑制蛋白2抗體 Anti-Socs 2
腦特異性跨膜蛋白抗體 Anti-NETO2
細(xì)胞因子信號(hào)傳導(dǎo)抑制蛋白1抗體 Anti-SOCS1
磷酸化微管相關(guān)蛋白抗體 Anti-phospho-Tau protein(Thr522)
Snail蛋白抗體 Anti-Snail/SNAI 1
神經(jīng)突觸素3抗體 Anti-Synapsin III
突觸相關(guān)蛋白25抗體 Anti-SNAP25
乳清蛋白α抗體 Anti-LALBA/alpha Lactalbumin
蛇毒蛋白抗體（中華眼鏡蛇） Anti-Snake poison Protein
蝮蛇蛇毒蛋白抗體 Anti-Echidnotoxin
衰老標(biāo)記蛋白30抗體 Anti-Regucalcin/SMP30 
細(xì)胞骨架相關(guān)蛋白抗體 Anti-SM22 Alpha