地中海熱蛋白MEFV抗體,Anti-MEFV抗體 返回列表頁

背景介紹：This gene encodes a protein, also known as pyrin or marenostrin, that is an important modulator of innate immunity. Mutations in this gene are associated with Mediterranean fever, a hereditary periodic fever syndrome. 

Function:
Involved in innate immunity and the inflammatory response. Interacts with several components of the inflammasome complex, a large oligomeric structure which recruits and activates CASP1 and ultimay induces maturation of cytokines such as IL1B. However, the exact role of MEFV in the inflammatory pathway is uncertain as contradictory effects on IL1B processing have been reported in different experimental systems. Has been shown to activate IL1B production (Ref.13). Has also been shown to inhibit IL1B production (Ref.14, Ref.15). Also required for PSTPIP1-induced PYCARD oligomerization and for formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Can reduce PYCARD-induced apoptosis. Recruits PSTPIP1 to pyroptosomes, and required for PSTPIP1 oligomerization.

別名：FMF; Marenostrin; Mediterranean fever; Mediterranean fever protein; MEF; Mefv; MEFV_HUMAN; Pyrin; TRIM20. 

地中海熱蛋白MEFV抗體,Anti-MEFV抗體簡單介紹：

產品編號：BYK-18750R

英文名稱：Anti-MEFV
中文名稱：地中海熱蛋白MEFV抗體

產品規格：50ul；100ul；200ul；1ml，*

抗體來源 Rabbit or Mouse

克隆類型 Polyclonal or Monoclonal

交叉反應、產品應用 （具體交叉反應與產品應用請或添加客服直接索取）

性    狀 Lyophilized or Liquid
濃    度 1mg/ml

地中海熱蛋白MEFV抗體,Anti-MEFV抗體產品信息：

博研生物小課堂：

常用激光器對應熒光素的選擇：

藍色激光器熒光素（488nm）：Alexa Fluor 488、FITC、PerCP、PerCP-Cy5.5、PE、PE-Cy5.5、PE-Cy5、PE-Cy7

紅色激光器熒光素（633nm）：APC、Cy5、APC-Cy5.5、APC-Cy7、Alexa Fluor 647

黃色激光器熒光素（561nm）：PE、PE-Cy5.5、PE-Cy5、PE-Cy7、Cy3、Alexa Fluor 555、Alexa Fluor 594

流式細胞術Flowcytometry：理：流式細胞術(flowcytometry FCM)是對單個細胞或其他生物微粒進行快速定量分析和分選的一門技術。在分析或分選過程中，包繞在流動液體中處理過的單個細胞或微粒通過聚焦的光源，產生電信號，這些信號代表光散射、熒光等參數，以此測定出細胞或微粒的物理和化學性質，并可根據這些性質分選出高純度的細胞亞群，以對其進一步的培養或分析。

應用：流式細胞術的功能決定了其在免疫學基礎研究中的廣泛應用，目前在臨床上主要用于細胞表型分析、造血系腫瘤診斷和分型、移植前配型及與免疫有關疾病分析等。

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