核蛋白NHN1抗體，ZC3H18抗體 返回列表頁

別名：Conserved nuclear protein NHN1; NHN1; Nuclear protein NHN1; zc3h18; ZCH18_HUMAN; Zinc finger CCCH domain-containing protein 18.  

背景介紹：NHN1 is a 953 amino acid nuclear protein that contains one C3H1-type zinc finger and exists as two alternatively spliced isoforms. The gene that encodes NHN1 contains more than 61,500 bases and maps to human chromosome 16q24.2. Encoding over 900 genes and consisting of approximay 90 million base pairs, chromosome 16 makes up nearly 3% of the human genome and is associated with a variety of genetic disorders. The GAN gene is located on chromosome 16 and, when mutated, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. Alterations in the CREB gene and NOD2 gene, both of which are located on chromosome 16, results in Rubinstein-Taybi syndrome and Crohn's disease, respectively. An association with systemic lupus erythematosis and a number of other autoimmune disorders with the pericentromeric region of chromosome 16 has led to the identification of SLC5A11 as a potential autoimmune modifier.

核蛋白NHN1抗體，ZC3H18抗體簡單介紹：

產品編號：BYK-18459R

英文名稱：Anti-NHN1
中文名稱：核蛋白NHN1抗體

產品規格：50ul；100ul；200ul；1ml，*

抗體來源 Rabbit or Mouse

克隆類型 Polyclonal or Monoclonal

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性    狀 Lyophilized or Liquid
濃    度 1mg/ml

核蛋白NHN1抗體，ZC3H18抗體產品信息：

抗原修復（免疫組化石蠟切片）

用于福爾馬林固定的石蠟包埋組織芯片需要抗原修復。

福爾馬林固定的組織有可能破壞了原來組織的抗原結構，蛋白多肽發生交聯，導致部分抗原表位封閉，結合位點減少，所以需要抗原修復，以暴露原來的抗原表位，達到充分顯露抗原，以不出現明顯脫片現象為佳。

抗原修復的幾種常用方法（供參考）

1、 微波爐加熱：

在微波爐里加熱0.01*緩沖液（pH6.0）至沸騰后將組織芯片放入，斷電，間隔5-10分鐘，反復1-2次。根據玻片情況可參考采用微波加熱“3-5-3法”3分鐘溫火沸騰后靜止5分鐘，再溫火沸騰3分鐘即可。

適用的抗原：來源于人、大鼠、小鼠的組織標本；來源于其他動物種屬的組織標本。

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