軸突導向受體蛋白3抗體，Anti-Robo3抗體 返回列表頁

軸突導向受體蛋白3抗體，Anti-Robo3抗體簡單介紹：

產品編號：BYK-10744R

英文名稱：Anti-Robo3
中文名稱：軸突導向受體蛋白3抗體

別名：HGPPS; HGPS; RB inhibiting gene 1; Rbig 1; Rbig1; Retinoblastoma inhibiting gene 1; Rig 1; Rig1; Robo 3; Robo3; Robo3 protein; ROBO3_HUMAN; Roundabout axon guidance receptor homolog 3; Roundabout homolog 3; Roundabout like protein 3; Roundabout, axon guidance receptor, homolog 3 (Drosophila); Roundabout-like protein 3.

背景介紹：This gene is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. ROBO proteins are a subfamily of the immunoglobulin transmembrane receptor superfamily. SLIT proteins 1-3, a family of secreted chemorepellants, are ligands for ROBO proteins and SLIT/ROBO interactions regulate myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, and vasculogenesis in addition to neurogenesis. This gene, ROBO3, has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin (Fn) type III motifs, a transmembrane segment, and a cytoplasmic tail with three conserved signaling motifs: CC0, CC2, and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family members, ROBO3 lacks motif CC1. The ROBO3 gene regulates axonal navigation at the ventral midline of the neural tube. In mouse, loss of Robo3 results in a complete failure of commissural axons to cross the midline throughout the spinal cord and the hindbrain. Mutations ROBO3 result in horizontal gaze palsy with progressive scoliosis (HGPPS); an autosomal recessive disorder characterized by congenital absence of horizontal gaze, progressive scoliosis, and failure of the corticospinal and somatosensory axon tracts to cross the midline in the medulla. Alternative transcript variants have been described but have not been experimentally validated.

產品規格：50ul；100ul；200ul；1ml，*

抗體來源 Rabbit or Mouse

克隆類型 Polyclonal or Monoclonal

交叉反應、產品應用 （具體交叉反應與產品應用請或添加客服直接索取）

性    狀 Lyophilized or Liquid
濃    度 1mg/ml

軸突導向受體蛋白3抗體，Anti-Robo3抗體產品信息：

合適的抗體稀釋度

抗體的濃度是免疫染色的關鍵，如果抗體濃度過高，抗體分子過多于抗原決定簇，可導致抗體結合減少，產生陰性結果。此陰性結果并不一定是缺少抗原，而是由于抗體過量，這種現象類似于凝集反應中的前帶效應（prozone effect）。因此，必須使用一系列稀釋做“棋盤式效價滴定”，檢測抗體的合適稀釋度，以得到zui大強度的特異性染色和zui弱的背景染色。抗體稀釋度應根據：1.抗體效價高，溶液中特異性抗體濃度越高，工作稀釋度越高；2.一般講，應用的抗體稀釋度越大，溫育時間越長；3.對于抗體與非特異性蛋白的結合，只有高稀釋度時才能防止其非特異性背景染色；4.稀釋用緩沖液的種類，標本的固定和處理過程等也可影響稀釋度，所以合適的稀釋度應根據具體情況測定。抗體的稀釋主要是指*抗體，因為*抗體中特異性抗體合適的濃度是關鍵，應用高稀釋度*抗體僅高親和力的特異性染色反應，減少或消除其中交叉抗體反應。

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